“Because we are renting we don’t get any compensation. This is a registered facility so if you move it somewhere else it’s all got to be re-registered and it costs £3,500 to do that.

“The only reason we are surviving now is we pay low rent on farm premises. We would be looking at £1,200 a month somewhere else and that would put us out of business.”

Farmer Jay How, 39, will lose 30 of his 200 acres at Wellwick Farm, near Wendover, where he lives with his wife Mary-Jane, 32, and daughters, Holly, eight, and Nicole, six.

He said: “I’m going to lose about £15,000 a year. They will compensate us for the loss of land but not for the loss of earnings.

“Of course we are angry but we can’t do anything about it. The farm has been in the family since 1925. I was never tempted to sell.”

Trevor Bratton, 71, and his wife Mo, 69, built their house just outside Wendover in the 1970s.

Mr Bratton said: “I wouldn’t be surprised if it had knocked £300,000 to £400,000 off the value. It would have been worth £1.2million.”

His wife added: “I think it’s going to be hell on Earth. Every weekend Wendover is buzzing with people from London. I’m sure they will stop coming. It’s going to hit the businesses hard.”

The Prideaux family, who have lived at Grade II listed Doddershall House in Quainton since it was built in 1520, will also suffer from HS2.

The line will run 250 yards from the house and a historic lodge will have to be knocked down.