A knee injury is threatening to sideline New York Giants wide receiver Mario Manningham for the first time since Week 3.

Manningham is officially questionable for Monday night’s matchup with the New Orleans saints after he was unable to practice this week.

Running back Ahmad Bradshaw (foot), defensive back Derrick Martin (hamstring) and linebacker Michael Boley (hamstring) did not practice for the third straight day Saturday. Bradshaw and Martin were ruled out, while Boley is listed as doubtful.

Defensive ends Osi Umenyiora and Justin Tuck were both listed as probable. Tuck missed practice Thursday with ankle and shoulder injuries, but returned to practice Friday and Saturday. 

Left tackle Will Beatty was ruled out earlier this week after undergoing surgery to repair a detached retina. Guard David Diehl is expected to move out to left tackle vs. the Saints, while Kevin Boothe will get the start at guard for Diehl.

The Saints listed linebacker Jonathan Vilma as questionable after he sat out practice on Saturday.